Macrophage migration inhibitory factor (MIF) plays a pivotal role in immunity against Salmonella typhimurium
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منابع مشابه
Macrophage migration inhibitory factor (MIF) plays a pivotal role in immunity against Salmonella typhimurium.
The cytokine macrophage migration inhibitory factor (MIF) exerts a multitude of biological functions. Notably, it induces inflammation at the interface between the immune system and the hypothalamus-pituitary-adrenal stress axis. The role of MIF in infectious diseases is not understood completely. Here, we show that MIF-deficient (MIF(-/-)) knockout mice fail to control an infection with wild-t...
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Authors: 5 Gunnar R. Husebø, Per S. Bakke, Rune Grønseth, Jon A. Hardie, Thor Ueland, Pål 6 Aukrust, Tomas M.L. Eagan. 7 8 Dept. of Thoracic Medicine, Haukeland University Hospital, Bergen Norway 9 2 Dept. of Clinical Science, University of Bergen, Norway 10 Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway 11 K.G. Jebsen Inflammatory Research Centre...
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Background MIF via its receptor, CD74, initiates a signaling cascade that leads to proliferation and survival of cells. Also, MIF binding to CD74 activates p38 signaling pathways that lead to positive effect on the expression of COX-2. The aim of this study was to evaluate the gene expression profile of MIF, CD74 and COX-2 in normal, ectopic and eutopic endometrium during menstrual cycle. The e...
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Abstract Background: Despite the long-standing association of macrophage migration inhibitory factor (MIF) with delayed-type hypersensitivity response, the potential role of MIF in chronic allograft nephropathy is unknown. The association between upregulation of MIF expression, macrophage and T cell infiltration and the severity of chronic allograft nephropathy suggests that MIF may be an ...
متن کاملHuman Macrophage Migration Inhibitory Factor (mif): a Proven Immunomodulatory Cytokine?
HUMAN MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF): A PROVEN IMMUNOMODULATORY CYTOKINE? Alex Kudrin‡, Martin Scott§, Steven Martin§, Chun-wa Chung§, Rachelle Donn¶¥, Andrew McMaster¥, Stuart Ellison¥, David Ray¶, Keith Ray‡, Michael Binks‡ From the ‡Department of Disease Biology, Rheumatology and Inflammation, GlaxoSmithKline, Stevenage, United Kingdom, SG1 2NY. §Discovery Research, GlaxoSmithK...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2002
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.212488699